Abstract
Although Covid-19 disease is primarily considered an infection of the respiratory tract, it is currently known that damage and adverse reactions in the course of and after this disease affect several other bodily systems, however these issues are not yet fully understood, especially in tangent its neurological manifestations.3,4 In this sense, this report aims to add the list of many cases that are being reported/described in the literature which warn about the direct effects of the virus on the nervous system, to a disease for -infectious or post-infectious immune-mediated to COVID-19, such as acute disseminated encephalomyelitis, muscular diseases of the peripheral nervous system (Guillain-Barré syndrome), cerebrovascular and vascular diseases (CVA), and acute inflammatory processes such as that of the brain parenchyma in this case of Viral Encephalitis. Encephalitis is a diffuse or focal inflammatory process of the brain parenchyma associated with brain dysfunction, which can be divided into two main categories: alluding to systemic infections or vaccination and alluding to the entry of the pathogen into the CNS. Thus, based on the premise that several neurological manifestations are related to SARS-CoV-2 infection, a better understanding of the immune response to this infection can help not only for prevention but also can provide a valuable contribution to knowledge of the health-disease process, next human approaches, therapeutic and drug interventions
References
2.COSTA, Bruna Klein da; SATO, Douglas Kazutoshi, “Encefalite viral: uma revisão prática sobre abordagem diagnóstica e tratamento”, Jornal de Pediatria (Rio de Janeiro), Porto Alegre, volume 96, suplemento 1, página 12-19, Março de 2020. Versão eletrônica acessada em 30.04.2021 em http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000700012&lng=en&nrm=iso. Edição publicada em 17 de abril de 2020, https://doi.org/10.1016/j.jped.2019.07.006.
3. LOPES, Cesar Castello Branco et al (2020), “Encefalomielite disseminada aguda associada a COVID-19: relato de dois casos e revisão de literatura”, Arquivo de Neuro-Psiquiatria, São Paulo, volume 78, número 12, página 805-810. Versão eletrônica acessada em 30.04.2021, em http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020001200805&lng=en&nrm=iso. Edição publica 07 de Dezembro de 2020, https://doi.org/10.1590/0004-282x20200186.
4. Gardênia Vargas (2020),” Estudo indica que Covid-19 pode causar danos cerebrais”, jornal público, de 22 de setembro. Versão eletrônica consultada em 30.04.2021, em https://portal.fiocruz.br/noticia/estudo-indica-que-covid-19-pode-causar-danos-cerebrais.
5. Ellul MA, Benjamin L, Singh B, et al. Neurological associations of COVID-19. Lancet Neurol. 2020;S1474-4422(20)30221-0. doi:10.1016/S1474-4422(20)30221-0
6. BRUZZONE, R.; DUBOIS-DALCQ, M.; GRAU, G. E.; GRIFFIN, D. E.; KRISTENSSON, K. Infectious diseases of the nervous system and their impact in developing countries. Plos Pathogens, v. 5, n. 2, p. 1-3, 2009.
7. Steiner I, Budka H, Chaudhuri A, et al. EFNS Task Force Viral encephalitis: a review of diagnostic methods and guidelines. Eur J Neurol 2005,12:331-43
8. LANE, J. H.; SASSEVILLE, V. G.; SMITH, M. O.; VOGEL, P.; PAULEY, D. R.; HEYES, M. P.; LACKNER, A. A. Neuroivasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/ micróglia and intrathecal immune activation. Journal of Neurovirology, v. 2, n. 6, p. 423-432, 1996.
9. CASSADY, K. A.; WHITLEY R. J. Pathogenesis and pathophysiology of viral infections of the central nervous system. In: SCHELD W. M.; WHITLEY, R. J.; MARRA, C. (Ed.). Infections of the central nervous system. 3 ed. Philadelphia: Lippincott Williams and Wilkins, p. 57-74, 2004.
10. Sonneville R, Klein I, Broucker T, et al. Post-infectious encephalitis in adults: Diagnosis and management. J Inf 2009;58:321-8
11. Sonneville R, Klein I, Broucker T, et al. Post-infectious encephalitis in adults: Diagnosis and management. J Inf 2009;58:321-8